Blueprint Medicines, a Sanofi company, is seeking an exceptional organic chemist to join our Process Chemistry group. This contract position resides within the Pharmaceutical Sciences organization. The candidate will work full-time onsite and execute laboratory activities related to the development of robust drug substance manufacturing processes across various phases of drug substance development. The ideal candidate will conduct multi-step organic synthesis, route scouting and optimization, purification and characterization of intermediates and final compounds to support drug substance scale-up activities.

An ideal candidate will have a strong foundation in modern synthetic organic chemistry and analytical techniques such as NMR, LCMS, UPLC/HPLC (Empower proficiency) and an understanding of early drug development processes and experiments. Experience in small-molecule process development and scale up is highly desired, however not required.

Responsibilities:

• Participate in the design, planning and execution of multi-step synthesis, process research and development as a cross-functional team member.
• Collaborate with cross-functional teams to ensure successful project outcomes.
• Implement process enhancements, scientific approaches and technical improvements to deliver robust chemical processes.
• Document and report experimental results and findings.
• Draft and review technical documents (development reports, patent applications, tech transfer documents etc.)
• Maintain an accurate, timely and compliant laboratory notebook.
• Maintain laboratory equipment and ensure compliance with safety regulations.

Qualifications:

• Strong knowledge of organic chemistry.
• Experience with early phase route development and process optimization
• Proficiency in using analytical instruments (HPLC/UPLC, NMR, LCMS) and software.
• Strong analytical and problem-solving skills.
• Strong written and verbal communication skills.
• Ability to work independently and as part of a team.
• Strong organizational and time management skills.

Capabilities:

• Ability to effectively prioritize and manage multiple tasks and compounds
• Ability to adapt to change and to work optimally within a variety of situations
• Ability to build productive working relationships across functions and highly diverse groups of individuals
• Self-motivated and willing to “learn on the job” and ask for assistance when needed
• Ability to make a significant impact in a results-driven environment where accountability is key.
• A team player, who listens effectively and invites response and discussion
• A collaborator who communicates in an open, transparent, complete, timely and consistent manner

An ideal candidate would have a B.S. or M.S. in Chemistry, or a related field with 3+ years of experience in pharmaceutical research or laboratory setting or, Ph.D. with 0-3 years of experience.